vinCRIStine sulfate /vinkris″tēn, -tin/ , an antimitotic antineoplastic. ▪ INDICATIONS: It is prescribed in the treatment of many neoplastic diseases, such as leukemia, neuroblastoma, lymphomas, and sarcomas. It is often used in combination therapy because its dose-limiting toxicity is different from that of most other cancer chemotherapy drugs. ▪ CONTRAINDICATIONS: Pregnancy, leukopenia, preexisting neuromuscular disease, or known hypersensitivity to this drug prohibits its use. Intrathecal administration of vincristine has caused deaths and is therefore also contraindicated. ▪ ADVERSE EFFECTS: Neurotoxicity is the dose-limiting toxicity. Constipation, abdominal pain, and alopecia also may occur. Vincristine is a vesicant, so prompt attention is required if extravasation occurs. Leukopenia seldom occurs at usual clinical doses but can become significant at higher doses.
