velocardiofacial syndrome /vel′ō·kär′dē·ō·fā′shəl/ , an autosomal-dominant syndrome of cardiac defects and characteristic craniofacial abnormalities, including cleft palate, jaw abnormalities, and prominent nose. It is often associated with abnormalities of chromosome 22. Learning disabilities occur often; short stature, slender hyperextensible hands and digits, scoliosis, cognitive impairment, inguinal hernia, auricular abnormalities, and microcephaly occur less frequently. Also called Shprintzen’s syndrome.