valrubicin, an antibiotic antineoplastic. ▪ INDICATIONS: This drug is used to treat bladder cancer. ▪ CONTRAINDICATIONS: Factors that prohibit the use of this drug include known hypersensitivity to anthracyclines or Cremophor EL, urinary tract infection, and small bladder size. ▪ ADVERSE EFFECTS: Life-threatening side effects of this drug include thrombocytopenia and leukopenia. Common side effects include anemia, nausea, vomiting, anorexia, diarrhea, urinary tract infection, urinary retention, hematuria, rash, and chest pain.