urticaria /ur′tiker″ē·ə/ [L, urtica, nettle] , a pruritic skin eruption caused by capillary dilation in the dermis that results from the release of vasoactive mediators, including histamine, kinin, and the slow reactive substance of anaphylaxis associated with antigen-antibody reaction. Also called hives. See also angioedema, cholinergic urticaria. −urticarial, adj. ▪ OBSERVATIONS: It is characterized by transient wheals of varying shapes and sizes with well-defined erythematous margins and pale centers. ▪ INTERVENTIONS: Treatment includes antihistamines and removal of the stimulus or allergen. ▪ PATIENT CARE CONSIDERATIONS: It may be a reaction to drugs, food, insect bites, inhalants, emotional stress, exposure to heat or cold, or exercise.