tuberous sclerosis, an autosomal dominant, neurocutaneous disease characterized by epilepsy, mental deterioration, adenoma sebaceum, nodules and sclerotic patches on the cerebral cortex, retinal tumors, depigmented leaf-shaped macules on the skin, tumors of the heart or kidneys, and cerebral calcifications. There is no effective treatment. Also called Bourneville’s disease, epiloia. See also adenoma sebaceum.
