tubercle /t(y)o̅o̅″bərkəl/ [L, tuber, swelling] , 1. a nodule or a small eminence, such as that on a bone. 2. a nodule, especially an elevation of the skin that is larger than a papule, such as Morgagni’s tubercles of the areolae of the breasts. 3. a small rounded nodule produced by infection with Mycobacterium tuberculosis, consisting of a gray translucent mass of small spheric cells surrounded by connective cells.