tretinoin /tret′inō″in/ , a retinoic acid derivative. ▪ INDICATIONS: It is prescribed in the topical treatment of acne vulgaris and fine wrinkles and is administered orally for inducing remission in acute promyelocytic leukemia. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or pregnancy prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects of topical administration are photosensitivity and red, edematous, blistered, or crusted skin. Almost everybody taking the drug orally experiences some degree of weakness, fatigue, headache, and fever, but adverse effects are seldom reasons for discontinuing use of the drug.
