tranylcypromine sulfate /tran′əlsip″rəmēn/ , a monoamine oxidase inhibitor that acts as an antidepressant. ▪ INDICATIONS: It is prescribed in the treatment of severe reactive or endogenous mental depression without melancholia and has an unlabeled use for the treatment of posttraumatic stress disorder. ▪ CONTRAINDICATIONS: Cerebrovascular or cardiovascular diseases, paranoid schizophrenia, liver dysfunction, alcoholism, pheochromocytoma, or known hypersensitivity to this drug prohibits its use. It is not given to children under 16 years of age. ▪ ADVERSE EFFECTS: Among the most serious adverse effects are severe hypertensive episodes that can be precipitated by ingestion of foods rich in tyramine or by concurrent administration of many sympathomimetic drugs. Common side effects include headache, vertigo, dry mouth, blurred vision, and orthostatic hypotension.
