trandolapril, an antihypertensive. Its prototype is enalapril. ▪ INDICATIONS: It is used to treat hypertension, heart failure, and postmyocardial infarction/left ventricular dysfunction. ▪ CONTRAINDICATIONS: Factors that prohibit its use include known hypersensitivity, a history of angioedema, and second- or third-trimester pregnancy. ▪ ADVERSE EFFECTS: Life-threatening effects include myocardial infarction, stroke, agranulocytosis, neutropenia, leukopenia, anemia, proteinuria, and renal failure. Other adverse effects include palpitations, angina, transient ischemic attacks, bradycardia, arrhythmias, paresthesias, headache, fatigue, drowsiness, depression, sleep disturbances, nausea, vomiting, cramps, diarrhea, constipation, ileus, pancreatitis, hepatitis, rash, purpura, dyspnea, hyperkalemia, hyponatremia, and impotence. Common side effects include hypotension, dizziness, dyspepsia, cough, and myalgia.
