timolol maleate /tim′əlōl/ , a beta-adrenergic receptor blocking agent. ▪ INDICATIONS: An ophthalmic preparation is used for treating glaucoma, especially chronic open-angle glaucoma. It is administered orally for the treatment of angina and hypertension, to reduce postmyocardial infarction mortality, and as migraine prophylaxis. ▪ CONTRAINDICATIONS: Bronchial asthma, chronic obstructive pulmonary disease, sinus bradycardia, cardiogenic shock, pregnancy (second or third trimester), or known hypersensitivity to this drug prohibits its use. It is used with caution in patients (e.g., diabetics) with contraindications to systemic use of beta-adrenergic receptor blocking agents. ▪ ADVERSE EFFECTS: The most serious adverse effects of ophthalmic use is blurring of vision. Mild eye irritation also may occur. When it is used systemically, adverse reactions include bronchospasm, cold extremities, decreased sexual ability, drowsiness, and insomnia.