tigecycline, a broad-spectrum antiinfective. ▪ INDICATIONS: This drug is used to treat complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycin-susceptible only), Staphylococcus aureus, Streptococcus agalactiae, S. anginosus group, S. pyogenes, Bacteroides fragilis and complicated intraabdominal infections caused by Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, K. pneumoniae, E. faecalis (vancomycin-susceptible only), S. aureus (methicillin-susceptible only), S. anginosus group, B. fragilis, B. thetaiotaomicron, B. uniformis, B. vulgatus, Clostridium perfringens, and Peptostreptococcus micros. ▪ CONTRAINDICATIONS: Pregnancy, lactation, and known hypersensitivity to this drug prohibit its use. Children under 18 years of age should not use this drug. ▪ ADVERSE EFFECTS: Adverse effects of this drug include headache; dizziness; insomnia; hypertension; hypotension; phlebitis; anorexia; constipation; dyspepsia; pruritus; sweating; photosensitivity; increased aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, lactic acid, alkaline phosphatase, and amylase; hyperglycemia; hypokalemia; hypoproteinemia; bilirubinemia; back pain; fever; abnormal healing; abdominal pain; abscess; asthenia; infection; pain; peripheral edema; and local reactions. Life-threatening side effects include anemia, leukocytosis, and thrombocytopenia. Common side effects include nausea, vomiting, and diarrhea.
