tetanus antitoxin (TAT), a tetanus immune serum that neutralizes exotoxins in tetanus infection. ▪ INDICATIONS: This drug is prescribed for short-term immunization against tetanus after possible exposure to the organism and in tetanus treatment. ▪ CONTRAINDICATIONS: This drug is not given if the more effective tetanus immune globulin is available or if there is a known sensitivity to equine serum. ▪ ADVERSE EFFECTS: Among the most serious adverse effects are allergic reactions and pain and inflammation at the site of injection.