spherocyte /sfir″əsīt/ [Gk, sphaira, sphere, kytos, cell] , an abnormal spherical red blood cell with a high cytoplasm-to-membrane ration. In Wright-stained peripheral blood films, spherocytes are dense, lack central pallor, and have a reduced diameter. Spherocytes appear most frequently in warm autoimmune hemolytic anemia and hereditary spherocytosis.
