sorafenib, a miscellaneous antineoplastic. ▪ INDICATIONS: This drug is used to treat advanced and metastatic murine renal cell carcinoma. ▪ CONTRAINDICATIONS: Pregnancy and known hypersensitivity to this drug prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include fatigue, weight loss, headache, anorexia, mouth ulceration, abdominal pain, constipation, pruritus, erythema, hand-foot rash, acne, flushing, and alopecia. Life-threatening side effects include hypertension, cardiac ischemia, infarction, pancreatitis, hemorrhage, leukopenia, lymphopenia, anemia, neutropenia, thrombocytopenia, and exfoliative dermatitis. Common side effects include nausea, diarrhea, vomiting, dry skin, hypophosphatemia, arthralgia, myalgia, and hoarseness.
