sirolimus, an immunosuppressant. ▪ INDICATIONS: It is used after organ transplantation to prevent rejection. Recommended use is in combination with cyclosporine and corticosteroids. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or any of its components prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects are anemia, leukopenia, thrombocytopenia, purpura, albuminuria, hematuria, proteinuria, renal failure, pleural effusion, atelectasis, and lymphoma. Other adverse effects include nausea, vomiting, diarrhea, constipation, hypertension, insomnia, chills, fever, urinary tract infections, hyperglycemia, increased creatinine, edema, hypercholesterolemia, hyperlipidemia, hypophosphatemia, weight gain, hyperkalemia, hyperuricemia, hypokalemia, hypomagnesemia, blurred vision, and photophobia. Common side effects include atrial fibrillation, congestive heart failure, hypotension, palpitations, tachycardia, tremors, headache, paresthesia, dyspnea, rash, and acne.
