silver sulfadiazine, a topical antibiotic. ▪ INDICATIONS: It is prescribed to prevent or treat infection in second- and third-degree burns. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug, to silver, or to sulfonamides prohibits its use. It is not given in the last weeks of pregnancy or to newborn or premature infants. ▪ ADVERSE EFFECTS: Among the most serious adverse effects are rash, fungal infection, neutropenia, and kernicterus.