Schedule of Drugs [L, scheda, sheet of paper; Fr, drogue] , a classification system that categorizes drugs by their potential for abuse. The schedule is divided into five groups: Schedules I to V. The assignment of drugs to the categories varies from state to state. Schedule I substances are not approved for medical use. All substances in Schedules II to V require a written prescription signed by a physician. Substances in Schedule V may or may not require a written prescription signed by a physician, depending on state law. Specific regulations for dispensing these substances vary from state to state and from institution to institution. See also controlled substance, Controlled Substances Act.