ranolazine, an antianginal drug. ▪ INDICATIONS: This drug is used in combination with other antianginals (such as amlodipine, beta-blockers, or nitrates) to treat chronic stable angina pectoris in those who have not responded to other treatment options. ▪ CONTRAINDICATIONS: Preexisting Q-T prolongation, hepatic disease (Child-Pugh class A, B, or C), hypokalemia, renal failure, torsades de pointes, ventricular arrhythmia, ventricular tachycardia, and known hypersensitivity to this drug prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include headache, dizziness, palpitations, nausea, vomiting, constipation, dry mouth, peripheral edema, and dyspnea. A life-threatening side effect of this drug is Q-T prolongation.
