Punnett square [Reginald C. Punnett, English geneticist, 1875–1967; OFr, esquarre] , a matrix that shows all of the possible combinations of male and female gametes when one or more pairs of independent alleles are crossed. Letters representing the male and female gametes are placed along the left side and the top of the matrix, respectively. The genotypes of the offspring produced by each pairing of gametes occupy the cells in the matrix. See also pedigree.