posaconazole, a systemic antifungal. ▪ INDICATIONS: This drug is used for prevention of aspergillus, Candida infection, and oropharyngeal candidiasis in the immunocompromised. ▪ CONTRAINDICATIONS: Fungal meningitis, onychomycosis or dermatomycosis in cardiac dysfunction, and hypersensitivity to this drug or other systemic antifungals or azoles prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include insomnia, fever, rigors, weakness, anxiety, hypertension, hypotension, tachycardia, anemia, cramps, abdominal pain, flatulence, gynecomastia, impotence, decreased libido, malaise, hypokalemia, and tinnitus. Life-threatening side effects include GI bleeding, hepatotoxicity, toxic epidermal necrolysis, and rhabdomyolysis. Common side effects include headache, dizziness, nausea, vomiting, anorexia, diarrhea, pruritus, edema, and fatigue.
