polythiazide /-thī·az″īd/ , a thiazide diuretic. ▪ INDICATIONS: It is prescribed as adjunctive therapy in the treatment of hypertension and edema. ▪ CONTRAINDICATIONS: Anuria or known hypersensitivity to this drug, other thiazides, or sulfonamide derivatives prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are hypokalemia, hyperglycemia, hyperuricemia, and various hypersensitivity reactions.