poikilocytosis /poi′kilō′sītō″sis/ [Gk, poikilos, variation, kytos, cell, osis, condition] , abnormal variation of red blood cell shape in a Wright-stained peripheral blood film. The term poikilocytosis is used only when the red blood cell shape cannot be more specifically defined. Compare sickle cell, target cell, ovalocytes, schistocyte.