plicamycin /plī′kəmī′sin/ , an antineoplastic agent. Formerly called mithramycin. ▪ INDICATIONS: It is prescribed primarily in the treatment of malignant tumors of the testis. It is also prescribed in the treatment of hypercalcemia and hypercalciuria associated with cancer. ▪ CONTRAINDICATIONS: Clotting disorders, thrombocytopenia, kidney or liver dysfunction, bone marrow depression, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are thrombocytopenia and clotting defects. Nausea and stomatitis commonly occur.
