Peutz-Jeghers syndrome /poits′ jeg′ərz/ [J.L.A. Peutz, Dutch physician, 1886–1957; Harold J. Jeghers, American physician, b. 1904] , an inherited disorder transmitted as an autosomal-dominant trait, characterized by multiple intestinal polyps and abnormal mucocutaneous pigmentation, usually over the lips and buccal mucosa. If obstruction or bleeding occurs, surgical removal of the polyps may be indicated.