periodic apnea of the newborn, a normal condition in the full-term newborn, characterized by an irregular pattern of rapid breathing followed by a brief period of apnea, usually associated with rapid eye movement (REM) sleep. Apnea in the newborn not associated with REM sleep or with periodic breathing is ominous because it is symptomatic of intracranial bleeding, seizure activity, infection, pneumonia, hypoglycemia, drug depression, or various cardiac defects. See also sudden infant death syndrome.