palonosetron, an antiemetic. ▪ INDICATIONS: This drug is used to prevent nausea and vomiting associated with cancer chemotherapy. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include abdominal pain, weakness, hyperkalemia, anxiety, rash, and arthralgia. A rare life-threatening side effect is bronchospasm. Common side effects include diarrhea, constipation, headache, dizziness, drowsiness, fatigue, insomnia, fever, and urinary retention.