osteopoikilosis /os′tē·ōpoi′kilō″sis/ [Gk, osteon + poikilos, mottled, osis, condition] , an inherited condition of the bones, transmitted as an autosomal-dominant trait, characterized by multiple areas of dense calcification throughout the osseous tissue, producing a mottled appearance on x-ray examination. It is a benign condition, usually without symptoms and of unknown cause. Also called osteosclerosis fragilis congenita. Also called osteosclerosis fragilis congenita. −osteopoikilotic, adj.