orphenadrine citrate /ôrfen″ədrēn/ , a skeletal muscle relaxant with anticholinergic and antihistaminic activity. ▪ INDICATIONS: It is prescribed in the treatment of severe muscle strain. ▪ CONTRAINDICATIONS: Myasthenia gravis, glaucoma or other contraindications to anticholinergic agents, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious adverse effects are those associated with anticholinergic activity, such as dry mouth and tachycardia, and allergic reactions.