oral-facial-digital (OFD) syndrome, type I, an X-linked dominant disorder lethal in males characterized by camptodactyly, polydactyly, and syndactyly; cranial, facial, lingual, and dental anomalies; and intellectual disability, familial trembling, alopecia, and seborrhea of the face and milia. Also called orodigitofacial dysostosis, orofaciodigital syndrome, type I.