opium tincture, an analgesic and antidiarrheal drug. ▪ INDICATIONS: It is prescribed in the treatment of intestinal hyperactivity, cramping, and diarrhea. ▪ CONTRAINDICATIONS: Drug dependence, the presence of toxic matter in the bowel, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are drug dependence, toxic megacolon, and central nervous system depression.