oogamy /ō·og″əmē/ [Gk, oon + gamos, marriage] , 1. sexual reproduction by the fertilization of a large nonmotile female gamete by a smaller, actively motile male gamete, such as occurs in certain algae and the malarial parasite Plasmodium. 2. (in biology) heterogamy. Compare isogamy. −oogamous, adj.