oligodendroglioma /ol′igōden′drōglī·ō″ mə/ pl. oligodendrogliomas, oligodendrogliomata [Gk, oligos + dendron, tree, glia, glue, oma, tumor] , an uncommon brain tumor composed of nonneural ectodermal cells that form part of the supporting connective tissue around nerve cells. The lesion, a firm reddish-gray mass with calcified spots and a distinct margin, may be large. The tumor develops most often in frontal, parietal, and paraventricular sites but also may occur in the cerebellum. Also called oligodendroblastoma.