Olestra, a synthetic fat substitute derived from sucrose and eight acids of vegetable oils. Olestra adds no calories or fats to the food into which it is incorporated. Because the molecules of Olestra are larger and more tightly packed than those of ordinary fats, they cannot be broken down by digestive enzymes and cannot enter the bloodstream. Adverse effects reported include cramping and loose stools in some people and inhibition of absorption of some vitamins. A newer formulation is fortified with certain fat-soluble vitamins.