odontogenic cyst, 1. a cyst derived from epithelium related to tooth development, usually containing fluid or semisolid material, that develops along lines of embryonic fusion or during various stages of tooth formation and development and is nearly always enclosed within bone. Odontogenic cysts are subclassified as developmental or inflammatory in origin. Kinds include dentigerous cyst, primordial cyst, odontogenic keratocyst, gingival cyst of the newborn, eruption cyst. 2. any of a variety of lesions of mouth tissues, including the relatively common dentigerous cyst, which is associated with the crown of an unerupted third molar or maxillary cuspid.