nystatin /nis″tətin/ , an antifungal antibiotic. ▪ INDICATIONS: It is prescribed in oral, topical, and vaginal formulations for the treatment of fungal infections of the GI tract, skin, and vagina. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug is the only contraindication. ▪ ADVERSE EFFECTS: There are no known serious adverse effects. Mild GI distress and mild skin reactions may occur.