nilutamide, an antineoplastic hormone. ▪ INDICATIONS: It is used to treat stage D2 metastatic prostatic carcinoma in combination with surgical castration. ▪ CONTRAINDICATIONS: Factors that prohibit the use of this drug include known hypersensitivity to nilutamide, severe hepatic impairment, and severe respiratory disease. ▪ ADVERSE EFFECTS: Hepatotoxicity and interstitial pneumonitis are life-threatening effects. Other adverse effects include hot flashes, drowsiness, insomnia, dizziness, hyperthesia, depression, decreased libido, impotence, testicular atrophy, urinary tract infection, hematuria, nocturia, gynecomastia, diarrhea, nausea, vomiting, increased liver function studies, constipation, dyspepsia, rash, sweating, alopecia, dry skin, dyspnea, upper respiratory infection, pneumonia, anemia, delayed adaption to the dark, and edema.
