neurosyphilis /-sif″ilis/ [Gk, neuron + sys, hog, philein, to love] , infection of the central nervous system by Treponema pallidum, the causative agent of syphilis, which may invade the meninges and cerebrovascular system. If the brain tissue is affected, general paresis may result. If the spinal cord is infected, tabes dorsalis may result. See also syphilis.