neurofibromatosis /no͝or′ōfī′brōmətō″sis/ [Gk, neuron + fibra, fiber; Gk, oma, tumor, osis, condition] , a congenital condition transmitted as an autosomal-dominant trait, characterized by numerous neurofibromas of the nerves and skin, café-au-lait spots on the skin, and developmental anomalies of the muscles, bones, and viscera. Many large, pedunculated soft-tissue tumors may develop. Bone changes may result in skeletal deformities, especially curvature of the spine. Neurofibromas may develop in the alimentary tract, bladder, endocrine glands, and cranial nerves. Also called multiple neuroma, neuromatosis, Recklinghausen’s disease, von Recklinghausen’s disease.
