necrosis /nekrō″sis/ [Gk, nekros + osis, condition] , localized tissue death that occurs in groups of cells in response to disease or injury. In coagulation necrosis, blood clots block the flow of blood, causing tissue ischemia distal to the clot. In gangrenous necrosis, ischemia combined with bacterial action causes putrefaction to set in. See also gangrene, coagulation necrosis, gangrenous necrosis.