mycophenolate mofetil, an immunosuppressant used to prevent rejection of allogeneic cardiac, hepatic, and renal transplants. It is administered orally or intravenously. ▪ INDICATIONS: It is used to prevent rejection of organ transplants and for prophylaxis of organ rejection in allogenic cardiac transplants. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or to mycophenolic acid prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects are leukopenia, thrombocytopenia, anemia, pancytopenia, renal tubular necrosis, and lymphoma. Other adverse effects are arthralgia, muscle wasting, and stomatitis. Common side effects are diarrhea, constipation, nausea, vomiting, rash, dyspnea, respiratory infection, increased cough, pharyngitis, bronchitis, pneumonia, tremor, dizziness, insomnia, headache, fever, peripheral edema, hypercholesterolemia, hypophosphatemia, edema, hyperkalemia, hypokalemia, hyperglycemia, urinary tract infection, hematuria, hypertension, chest pain, and nonmelanoma skin carcinoma.
