MOPP /mop/ , a combination drug regimen used in the treatment of cancer that contains three antineoplastics, Mustargen (mechlorethamine hydrochloride), Oncovin (vincristine sulfate), and Matulane (procarbazine hydrochloride), plus prednisone (a glucocorticoid). MOPP is prescribed in the treatment of Hodgkin’s disease. Abbreviation for Mustargen, Oncovin, procarbazine hydrochloride, prednisone.