metyrapone /metir″əpōn/ , a diagnostic test drug. ▪ INDICATIONS: It is used to test hypothalamic and pituitary function. ▪ CONTRAINDICATIONS: Adrenocortical insufficiency or hypersensitivity prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious adverse effects are nausea, dizziness, and allergic rash.