mesoridazine /mez′ərid″əzēn/ , a phenothiazine antipsychotic drug. ▪ INDICATIONS: It is prescribed in the treatment of schizophrenia. ▪ CONTRAINDICATIONS: Parkinson’s disease, concurrent administration of central nervous system depressants, liver or renal dysfunction, severe hypotension, or known hypersensitivity to this drug or to other phenothiazine medications prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are prolongation of the QT interval (increases risk of torsades de pointes arrhythmia), hypotension, liver toxicity, a variety of extrapyramidal reactions, persistent tardive dyskinesia, blood dyscrasias, and hypersensitivity reactions.
