meningococcal polysaccharide vaccine /-kok″əl/ , one of four active immunizing agents against group A, group C, group Y, or group W-135 meningococcal organisms. ▪ INDICATIONS: It is prescribed for immunization against meningococcal meningitis, with the serogroup matched according to the local outbreak. ▪ CONTRAINDICATIONS: Immunosuppression or acute infection prohibits its use. ▪ ADVERSE EFFECTS: The most serious adverse effect is anaphylaxis.