medroxyPROGESTERone acetate /medrok′sēprōjes″tərōn/ , a progestin. ▪ INDICATIONS: It is prescribed in endometrial and renal carcinomas and in the treatment of menstrual disorders caused by hormone imbalance. It is given as a depot injection for contraception (Depo-Provera). ▪ CONTRAINDICATIONS: Known or suspected pregnancy, thrombophlebitis, embolism, stroke, liver dysfunction, cancer of the breast or genitals, abnormal vaginal bleeding, missed abortion, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are thrombophlebitis, pulmonary embolism, stroke, hepatitis, and cerebral thrombosis.
