maprotiline hydrochloride /maprō″tilēn/ , a tetracyclic antidepressant similar to the tricyclics. ▪ INDICATIONS: It is prescribed for the treatment of depression. ▪ CONTRAINDICATIONS: It is used with caution in conditions in which anticholinergics are contraindicated, in seizure disorders, and in cardiovascular disorders. Concomitant administration of monoamine oxidase inhibitors, recent myocardial infarction, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are sedation and anticholinergic side effects. A variety of GI, cardiovascular, and neurological reactions (including convulsions) may occur. Like the tricyclics, it is involved in many potential drug interactions.
