Mantoux test /manto̅o̅″/ [Charles Mantoux, French physician, 1877–1947] , a tuberculin skin test that consists of intradermal injection of a purified protein derivative of the tubercle bacillus. A hardened, raised red area of 8 to 10 mm, appearing 24 to 72 hours after injection, is a positive reaction. This method is the most reliable means of testing tuberculin sensitivity. See also tuberculin test.