mandibulofacial dysostosis /mandib′yəlofā″shəl/ [L, mandere + facies, face; Gk, dys, bad, osteon, bone] , an abnormal hereditary condition characterized by an antimongoloid slant of the palpebral fissures, coloboma of the lower lid, micrognathia and hypoplasia of the zygomatic arches, and microtia. Evidence indicates that this disorder is transmitted as an autosomal-dominant trait. The condition occurs in the complete form as Franceschetti’s syndrome and in the incomplete form as Treacher Collins’ syndrome. See also dysostosis.
