mafenide acetate /maf″ənīd/ , a topical antibiotic. ▪ INDICATIONS: It is prescribed in the treatment of second- and third-degree burns to prevent infection by microorganisms such as Pseudomonas aeruginosa. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or to sulfonamide prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are hypersensitivity reactions and superinfections, particularly by Candida albicans.