losartan, an antihypertensive drug. ▪ INDICATIONS: It is used to treat hypertension, either alone or in combination with other drugs. ▪ CONTRAINDICATIONS: Factors that prohibit the use of this drug are known hypersensitivity to tramadol and second- and third-trimester pregnancy. ▪ ADVERSE EFFECTS: Life-threatening effects are cerebrovascular accident and myocardial infarction. Other adverse effects are anxiety, confusion, abnormal dreams, migraine, tremor, vertigo, task perversion, angina pectoris, second-degree atrioventricular block, hypotension, blurred vision, burning eyes, conjunctivitis, anorexia, constipation, dry mouth, flatulence, gastritis, vomiting, impotence, nocturia, urinary frequency, urinary tract infection, anemia, alopecia, dermatitis, dry skin, flushing, photosensitivity, rash, pruritus, sweating, gout, cramps, myalgia, pain, stiffness, congestion, dyspnea, and bronchitis. Common side effects are dizziness, insomnia, arrhythmias, diarrhea, dyspepsia, cough, and upper respiratory infection.